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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K1
All Species:
29.7
Human Site:
S25
Identified Species:
50.26
UniProt:
Q02750
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02750
NP_002746.1
393
43439
S25
S
A
V
N
G
T
S
S
A
E
T
N
L
E
A
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
S25
S
A
V
N
G
T
S
S
A
E
T
N
L
E
A
Rhesus Macaque
Macaca mulatta
XP_001110225
393
43444
S25
S
A
V
N
G
T
S
S
A
E
T
N
L
E
A
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P31938
393
43456
S25
S
A
V
N
G
T
S
S
A
E
T
N
L
E
A
Rat
Rattus norvegicus
Q01986
393
43447
S25
S
A
V
N
G
T
S
S
A
E
T
N
L
E
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511248
391
43070
A44
L
R
I
F
L
S
R
A
A
L
K
S
G
D
L
Chicken
Gallus gallus
Q90891
398
44059
A28
G
P
G
P
G
G
S
A
E
A
N
L
V
D
L
Frog
Xenopus laevis
Q05116
395
43724
T25
T
A
V
N
G
T
P
T
A
E
T
N
L
E
A
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
S28
K
G
E
M
S
V
P
S
N
V
R
G
K
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24324
396
43851
P33
P
T
P
P
F
K
T
P
S
G
T
D
T
H
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10664
387
42776
T28
Q
S
E
S
G
E
A
T
A
E
E
A
T
A
T
Sea Urchin
Strong. purpuratus
XP_781505
412
45737
T41
T
T
A
T
E
K
S
T
S
G
I
K
V
D
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
Q28
S
I
T
K
F
L
T
Q
S
G
T
F
K
D
G
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
S38
S
A
V
K
R
T
S
S
T
S
S
H
Y
N
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
99.7
N.A.
N.A.
98.9
99.2
N.A.
73
81.6
91.9
33.3
N.A.
62.3
N.A.
52.4
64.8
Protein Similarity:
100
99.2
100
N.A.
N.A.
99.4
99.7
N.A.
77.8
88.9
96.1
51.4
N.A.
77.7
N.A.
69.2
75.7
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
6.6
13.3
80
6.6
N.A.
6.6
N.A.
20
13.3
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
40
33.3
93.3
13.3
N.A.
33.3
N.A.
46.6
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
34.3
20.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.4
33.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
50
8
0
0
0
8
15
58
8
0
8
0
8
50
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
8
0
29
0
% D
% Glu:
0
0
15
0
8
8
0
0
8
50
8
0
0
43
0
% E
% Phe:
0
0
0
8
15
0
0
0
0
0
0
8
0
0
0
% F
% Gly:
8
8
8
0
58
8
0
0
0
22
0
8
8
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% H
% Ile:
0
8
8
0
0
0
0
0
0
0
8
0
0
0
0
% I
% Lys:
8
0
0
15
0
15
0
0
0
0
8
8
15
8
8
% K
% Leu:
8
0
0
0
8
8
0
0
0
8
0
8
43
0
15
% L
% Met:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
43
0
0
0
0
8
0
8
43
0
8
8
% N
% Pro:
8
8
8
15
0
0
15
8
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% Q
% Arg:
0
8
0
0
8
0
8
0
0
0
8
0
0
0
0
% R
% Ser:
50
8
0
8
8
8
58
50
22
8
8
8
0
0
8
% S
% Thr:
15
15
8
8
0
50
15
22
8
0
58
0
15
0
8
% T
% Val:
0
0
50
0
0
8
0
0
0
8
0
0
15
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _